New Ways to Detect the Genesis of Seizures

new ways to detect the genesis of seizures

You probably know about epilepsy and the devastation associated with it. May be you are even a victim. There is, however, some good news hovering around the corners. Researchers are currently working on new efforts to predict the cause of these seizures. Moreover, new technology is progressively being developed on ways to predict the seizures. The team is led by some leading researchers from a top tech company.

The researchers are working closely together with neurologists and experts from leading centers. These experts aim to come up with a unique computer system that works more like an artificial brain. The computer will, however, be programmed to carry out are a real human brain analysis.

The new software application is intended to make an interpretation of the human brain waves using a neural network. In this process, the proprietary computer hardware will analyze the brain waves of a patient. It is thought that this will become possible when the brain waves are channeled into the neural network. Of course, such efforts require much coordination to become a success.

The technology utilized in these endeavors is an experimental chip that was developed by IBM. It is called the TrueNorth. The device is designed with the kind of architecture that mirrors the human brain. For this reason, it is able to accomplish an efficient neural network.

The researchers work by connecting the computer chip to an external computer. This, in turn, connects to a wearable device that works together with a brain implant. The implant further sends an EEG-type of information to the computer or the wearable device. Finally, the computer will use this data in predicting exactly when an epileptic seizure is expected to happen.

Notably, the researchers want the new system to be available soon on a wearable device. This would help them carry out efficient analysis in real time. Further, they said that they only way for this technology to have a significant impact beyond existing on paper is to have the device working efficiently to help users.

It is expected that the new device will have the capacity to detect oncoming seizure. This will alert the patient and the doctors by means of a connecting smart phone. Moreover, the researchers expect to use the data obtained from these earlier studies on special implants. They hope to understand more about the underlying mechanisms of the brain activity in the course of a seizure.

It is the hope of researchers that this newly gathered information will help them refine the device to the extent that it can be used to stop the seizures altogether, well before they occur. The lead researcher, Stefan Harrer added that the device is expected to work in place of a malfunctioning brain. In effect, the computer would be compensating for the deficiencies of the brain. This is what will, ultimately, enable the device to stop the seizure.

Regardless, the researchers have encountered plenty of challenges on the road to making these new discoveries. For instance, from the onset, it has been a problem for the scientists to extract meaningful information from the noise generated by a patient’s brain. To do this, they have to find a means to detect a specific pattern of seizure for individual patients. Well, this has so far eluded them. They, however, say that they are inching closer to this every day.

For many people, the whole thing sounds much like a scene out of a science fiction movie. In reality, it seems that this is far beyond a mere unreality.

To illustrate, for a long time neurologists working from the University of Melbourne have been conducting studies involving less complex readings obtained from EEG implants attached to selected epilepsy patients. These studies have gone on for more than three years. Indeed, Harrer merely joined up with the team to make a success of their efforts.

Ultimately, the long term goal of these endeavors is that one day they will be able to connect an artificial network of neural to a live human body. Of course, this might happen many years in future. The researchers, however, believe that, not only will this become a reality, it must happen.

Squarespace Financial Outlook Fiscal Year 2021

squarespace financial outlook fiscal year 2021

Squarespace, Inc. (the "Company"), the all-in-one website building and ecommerce platform that enables millions to build a brand and transact with their customers in an impactful and beautiful online presence, today issued guidance for its second quarter ending June 30, 2021 and for the full year ending December 31, 2021.

Financial Outlook - For the second quarter of fiscal year 2021, the Company currently expects: Revenue of $186 million to $189 million, representing year-over-year growth of 24% to 26%. Non-GAAP unlevered free cash flow (uFCF) of $10 million to $13 million. This is the result of: Cash flow from operating activities of $10.6 million to $14.0 million (which includes approximately $32 million of one-time expenses related to the Company's direct listing) minus. Capital expenditures, expected in the range of $2.6 million to $3.2 million; plus. Cash paid for interest expense net of associated tax benefit, expected in the range of $2.0 million to $2.2 million.

For the full fiscal year 2021, the Company currently expects:

Revenue of $764 million to $776 million, representing year-over-year growth of 23% to 25%. Non-GAAP unlevered free cash flow (uFCF) of $100 million to $115 million. This is the result of: Cash flow from operating activities of $111.0 million to $128.8 million (which includes approximately $35 million of one-time expenses related to the Company's direct listing) minus. Capital expenditures, expected in the range of $19.4 million to $23.7 million; plus. Cash paid for interest expense net of associated tax benefit, expected in the range of $8.4 million to $9.9 million.

"After a strong first quarter 2021, we expect to see continued momentum in the business in the second quarter and for the remainder of the year. We believe that a beautiful and impactful online presence, and supporting entrepreneurs and creators with the ability to transact online, will help drive more unique subscriptions to our platform throughout 2021. Further, we believe the recent additions of new products will allow us to develop deeper relationships with our customers as they find more value in our all-in-one solution. Finally, we are excited about our recent acquisition of Tock, which provides us with the ability to better address the large hospitality opportunity by enabling restaurants to adapt and grow with new ways of transacting directly with their customers," said Marcela Martin, CFO of Squarespace.

Squarespace's revenue in Q1 grew 31% versus the prior year. Squarespace derives revenue from monthly and annual subscriptions and non-subscription services. Subscription revenue accounted for 94% of its total revenue in the three months ended March 31, 2021. Revenue is further categorized as either Presence or Commerce depending on the nature of the service provided to the customer. Presence revenue primarily consists of fixed-fee subscriptions to the Company's plans that offer core platform functionalities. Additionally, presence revenue consists of fixed-fee subscriptions to third-party software solutions, fixed-fee subscriptions to social media stories, and domain managed services. Presence revenue of approximately $133 million grew approximately 20% in three months ended March 31, 2021 versus the prior year. Commerce revenue primarily consists of fixed-fee subscriptions to the Company's commerce plans, non-subscription revenue derived from revenue share arrangements with commerce partners, and transaction fees earned on sales made through customers' sites. Commerce revenue of approximately $47 million grew approximately 78% in the three months ended March 31, 2021 versus the prior year.

Forward Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements other than statements of historical fact are forward-looking statements. These statements include, but are not limited to, statements regarding the Company's future operating results and financial position, including for its second fiscal quarter ended June 30, 2021 and its fiscal year ended December 31, 2021. The words "believe," "may," "will," "estimate," "potential," "continue," "anticipate," "intend," "expect," "could," "would," "project," "plan," "target," and similar expressions are intended to identify forward-looking statements. Forward-looking statements are based on management's expectations, assumptions, and projections based on information available at the time the statements were made. These forward-looking statements are subject to a number of risks, uncertainties, and assumptions, including risks and uncertainties related to: the Company's ability to attract and retain customers and expand their use of its platform; the Company's ability to improve and enhance the functionality, performance, reliability, design, security and scalability of its solutions; the Company's ability to compete successfully against current and future competitors; the impact of the COVID-19 pandemic on the Company; the Company's ability to protect or promote its brand; the Company's ability to generate new customers through its marketing and selling activities; the Company's ability to hire, integrate and retain its personnel; the reliability, security and performance of the Company's software; the Company's ability to adapt to changes to technologies used in its platform or new versions or upgrades of operating systems and internet browsers; the Company's compliance with privacy and data protection laws and regulations as well as contractual privacy and data protection obligations; and risks associated with international sales and the use of the Company's platform in various countries. It is not possible for the Company's management to predict all risks, nor can it assess the impact of all factors on its business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements the Company may make. In light of these risks, uncertainties, and assumptions, the Company's actual results could differ materially and adversely from those anticipated or implied in the forward-looking statements. Further information on risks that could cause actual results to differ materially from forecasted results are included in the Company's filings with the Securities and Exchange Commission ("SEC") including its Form S-1/A filed on May 3, 2021 with the SEC. Except as required by law, the Company assumes no obligation to update these forward-looking statements, or to update the reasons if actual results differ materially from those anticipated in the forward-looking statements.

About Squarespace

Squarespace is a leading all-in-one website building and ecommerce platform that enables millions to build a brand and transact with their customers in an impactful and beautiful online presence. Our suite of products enables anyone at any stage of their journey to manage their projects and businesses through websites, domains, ecommerce, marketing tools, and scheduling, along with tools for managing a social media presence with Unfold and hospitality business management via Tock. Squarespace democratizes access to best-in-class design, helping our customers in approximately 180 countries maintain consistent branding across all digital touchpoints to stand out online. Our team of more than 1,200 is headquartered in downtown New York City, with offices in Dublin, Ireland, Portland, Oregon, and Los Angeles, California.

US Economic and Financial Status Beyond 2021

us economic and financial status beyond 2021

With unemployment rate 6.1% at everyone knows that, for decades, the US has fought the unemployment crisis viciously. The Obama administration bore the brunt of the blame in its last years in power. There were even some startling layoffs in the tech industry and, most surprisingly, in the military. Nevertheless, seemingly, the nation is fast recovering from the effects of this problem. The job market, in 2020, is slowly rising from the ashes. Arguably, more and more people are changing status from being unemployed to employed. However, no one should doubt that unemployment is still a major issue in America today.

What has caused all these troubles for the world's surviving superpower? Do not be deceived. None of this happened overnight. It has taken root gradually, stealthily and steadily. The economy slid to instability slowly, heading to unwanted areas. The prices of items have risen to an all-time high.

Without a doubt, the effects of inflation has confidently reared its ugly head, again. What is more, the US dollar has significantly lost value in the world financial markets. Even the cost of certain essential aspects of the economy has skyrocketed phenomenally. This includes the cost of accessing health care, education and property prices.

Have you heard about the academic Theory of Economic Cycle? This is the theory that helped predict financial market peaks and collapses in the past centuries. Of course, like with everything else, many believe in this theory. Many others don't. Regardless, basing on this, what are some academic predictions touching on the US in 2020 and beyond?

Well, the forecast is startling. It says that the US is hurtling towards one of the worst financial crises in history. Will this prove to be true? It is well known that the US, although considered one of the richest nations on earth, has a huge gap between the rich and the poor. If this report came true, how would it impact on the citizen's life? Indeed, what circumstances would precipitate such a crisis?

There is no sign that the ordinary man's income status or wages will go up anytime soon. Things are certainly not promising. The wages of most workers have remained stagnant rather than improve. It is interesting to note that the US economy and market has always been characterized by a consumer-based modus operandi. For this reason, the average consumer is always being encouraged to spend more.

What has been the overall effect of such an economic impetus? Well, the consumer, faithful to the hook, has always done exactly as prompted by the gurus of the national economic dynamics. Without disappointing, the consumers have always gone out of their way to spend everything; to the last coin. After all, have they not been encouraged to do so by those who know better? The experts have spoken. Who is the consumer not to follow suit and make the gurus proud? So, ‘spend more and more' has been the silent maxim followed by the ordinary consumer in the US. And this has gone on for decades.

The result? The average consumer has been increasingly forced to borrow more and more. The ordinary consumer is ever digging deeper into the pockets, even making use of credit facilities to fill the gaps that, predictably, come. What is the effect of such a situation?

Simple. The rich are getting richer. The poor are getting poorer. As the consumer spends more, rich investors, who manufacture the products loved by the consumer, will have more money thrust into his pocket. The rich will make more money. This monies are further invested in the manufacturing and other sectors. Soon, more goods will flood the market. The consumer gets excited. He borrows more money to get these dear goods. And the cycle continues.

Of course, this is typically how the gap between the rich and poor widens by the day. Yes, the rich get richer while the poor get poorer. This is a sad fact of life in modern America: 90% of the population has become a hapless victim of such a sorry state of affairs. The US economy is, therefore, currently overburdened with ballooning debt. As a result of inflation, more and more workers are being laid off from their jobs. There is an increased need to borrow more and more to fill this gap.

What is the ultimate result? Predictably, inflation will keep soaring. Interest rates will follow suit, also going up. There will, eventually, be less economic activity to hoist anyone out this sorry situation. We cannot deny the fact that this is the current situation in the country. Any denial of this won't solve the issue. Yes, again, economic decline and stagnation is certainly here with us.

US Dollar Stable Despite Economic Upheavals

us dollar stable despite economic upheavals

The US dollar is known worldwide as the most valuable currency for carrying out business transactions. Despite ups and downs, a stable currency can, over time, retain its purchasing power, and the US Dollar is no different. Certainly, the dollar is one of the most frequently used currencies globally; it accounts for over 85% of the world's business transactions. Further, the dollar has been able to stand the test of time regarding other leading currencies such as the Euro, the Sterling Pound, and the Yen.

Statistics show the US Dollar made a significant jump on the stability index in the past year alone, and this is because of how stable the dollar has continued to be. Further, many countries use the dollar as their official currency. These include countries like Panama. In addition to the US economy's strength, "size" is a primary factor contributing to this stability. The US economy is the biggest globally, with a Gross domestic product of over $20 trillion. The dollar's strength continues to rise since it funds the vast US economy.

Think of it: The International Monetary Bank (IMF) is a financial institution that improves its member countries' economies. According to the organization, over 60% of foreign banks' reserve cash is in Dollars. Further, many loans which are provided to countries all over the world exist in dollars. This preference of transacting using the dollar makes the currency quite stable; its value is always increasing from a financial perspective.

Generally, banking institutions significantly contribute to the dollar's stability. Further, banks' interest rates (Federal funds rate) have a ripple effect on the economy's interest rates. These high rates make the dollar stable as the value of the dollar rises progressively. Also, foreign investors usually seek to put their capital into the economy; they want higher returns on bonds and investments.

The sale of these investments will always make the dollar's exchange rate soar hence boosting its stability. Because of the financial crisis of 2008, the Federal Reserve raised the federal funds rate. This rate rise resulted in a shortage of money supply in the larger economy. Ultimately, the dollar became more stable. Borrowing the dollar became more expensive as its value had significantly risen.

Certainly, inflation levels in the US also contribute to the dollar's stability. If there are high inflation levels in the country, people spend more, resulting in higher prices for goods and services. Notably, investors with bonds will get higher fixed returns during high inflation levels, hence the dollar's stability. Inversely, low inflation levels indicate a weak economy and a weak Dollar, as people's purchasing power falls dramatically.

The US Department of Treasury manages treasury notes sold to investors at fixed interest rates from time to time. These notes affect the dollar's strength and its overall stability. High demand for these notes prompts investors to pay more for the notes than their original face value, resulting in a lower yield for the investors and vice versa. A high yield indicates the dollar is in low demand and hence its diminished strength. For instance, in 2016, the dollar strengthened as treasury notes yield fell to 2.4%. This indicated that the dollar was relatively stable at the time.

Many countries worldwide have foreign cash reserves in Dollars. These countries' exports enable them to hoard more dollars when they get paid in dollars for exports. Countries like Japan and China are fond of this hoarding, enabling their currencies' value to remain lower. However, the rise of the dollar makes these reserves' value rise, prompting these countries to acquire more dollar currencies in the form of imports. This makes the dollar's value rise and hence its overall stability.

Finally, the financial markets are another reason why the dollar continues to be stable. In many foreign exchange markets, over 80% of the trade involves using the dollar. Further, being the most significant financial market globally, the dollar’s preference has made its value rise consistently. In turn, this has made the currency more stable. Ultimately, the dollar is the most traded currency pair in the market; many traders pair the dollar with other currencies when carrying out their trade. This preference certainly contributes to the dollar's admirable stability and fortitude.